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Multiple Choice: Steroid hormone mechanism of action and metabolism Question 1. Which of the following statements best reflects the activity of sex steroids after they leave their gland of origin? A Most steroid hormones are not bound to specific transport proteins as they circulate in the bloodstream B Once inside the cell, a steroid can only produce responses in cells that have specific intracellular receptors for that hormone C Steroids require transport proteins to enter cells D Androgens, progestins and estrogens each have a unique sequence of events from entry into cells to protein synthesis