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Multiple Choice: Chapter 22 Respiratory conditions II Question 1 What is pharmacologically different about sedating and non-sedating antihistamines that accounts for the difference in side effects? A Non-sedating antihistamines are more receptor specific B Non-sedating antihistamines are less lipid soluble C Sedating antihistamines remain in the body for longer D Sedating antihistamines increase the production of the sleep hormone melatonin