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Self-Assessment Questions 3. Steroid hormone mechanism of action and metabolism Name two things that can increase sex hormone-binding globulin (SHBG) synthesis and two things that can decrease its synthesis. Show Answer Correct answer: Pregnancy, estrogen and hyperthyroidism can increase SHBG synthesis. Androgens, progestins, corticoids and growth hormone all decrease SHBG synthesis. Print Answers | « Previous Question | Next Question »